Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its ACE counterpart, ACE2 expression is restricted to the heart, kidney, and testis. Recently.
ACE2 has also been shown to be a functional receptor for the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. Although the role of these vasoactive peptides is not well understood, the lack of expression of ACE2 in ace2- / ace2- mice leads to severely reduced cardiac contractility, indicating their importance in the regulation of cardiac function.
ACE 2; ACE-related carboxypeptidase; ACEH; angiotensin-converting enzyme I (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme I 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; angiotensin-converting enzyme related carboxypeptidase; MPROT15 metalloprotease; peptidyl dipeptidase A; Processed angiotensin transforming enzyme 2; renal angiotensin-converting enzyme 2